P7 - Physiological and pathological brain networks in epilepsy
- P.Kahane (CHU Grenoble), N.Ravel et J.C.Dreher (ISC-CNRS, Lyon), E.Procyk (U371, Lyon), O. Jensen (Center for Neuroimaging, Nijmegen), T. Gruber (Univ. Leipzig)
- MEG, EEG, intra EEG, fMRI
We know that mental processes involve networks of neural structures distributed in the brain and interacting dynamically. An influential working hypothesis, proposed about fifteen years ago, suggests that oscillatory activities within these networks, and interactions (by synchronization/de-synchronization) between regions, could constitute one of the neurophysiological substrate of the brain dynamics. This hypothesis has been partially supported by experimental reports in animal and human obtained at different recording levels (unit activity, local field potential, intracranial and surface EEG, MEG). For the last 10 years, our laboratory has largely contributed to this field of research, with pioneering works in humans on beta/gama oscillations (>20Hz) induced by different experimental situations (sensory integration and feature binding, attention, memory). In this project, transversal across the laboratory by nature, and interacting with other external research teams, we will improve our understanding of the origin and the functional role of oscillations from different complementary perspectives:
- by interacting with most of the other projects for which the "oscillatory" approach will shed light on the dynamics of the studied functions, thus reciprocally increasing the number of cognitive situations explored.
- by a comprehensive fusion of the different levels of recording in Humans within a precise anatomical framework. For instance, thanks to their excellent spatial resolution, intracranial EEG signals could provide solid grounds for the interpretation of oscillations observed at a more macroscopic level (EEG/MEG). In the same vein, our studies aiming at bridging the gap between electrophysiology and fMRI signal (BOLD) will continue.
- by developing methods allowing to better localize the oscillatory activities from non-invasive recordings (EEG/MEG), and to better characterize the coupling/de-coupling dynamics, with appropriate statistical analysis (randomization techniques). Specific efforts will be devoted to the MEG approach.
- by trying to parallel these results with those obtained at more microscopic level (unit and multi-unit activities, local field potentials) in rats or monkeys in behavioural situations (external collaborations).
- by investigating how certain sensori-cognitive deficits could be correlated to a perturbation of these oscillatory networks (in epilepsy and schizophrenia for instance).
This project stands at the junction of cognitive questions, methodological innovations, and clinical issues. It aims at providing a more refined and comprehensive view of the brain oscillatory activities.
Publications since 2014