P6 - Cognition markers in altered states of consciousness

People

• Coordinator : Dominique MORLET Researcher, Catherine FISCHER Hospital MD
• Permanent staff : Olivier BERTRAND Researcher, Head of the lab, Perrine RUBY Researcher

External collaborations

• Iréna HOLECKOVA

• Neurological Hospital, Lyon:
• Functional Neurology and Epileptology (N.André-Obadia, C.Fischer),
• Anesthesia and Neuro-reanimation (F.Dailler, T.Lieutaud, C.Bodonian)
• Henri Gabrielle Hospital, Lyon:
• Neurological functional reeducation(J.Luauté)
• Cardiological Hospital, Lyon:
• Intensive Care Unit (G. Kirkorian)
• Micromed 

Approaches

• Scalp EEG

Key words

• Event-related potentials, ERPs, N100, mismatch negativity, MMN, P300, coma, vegetative state, minimally conscious patients.

Research Theme

Auditory evoked potentials are cerebral responses to auditory stimuli, recorded by electrodes attached to the scalp.

Appropriate auditory paradigms elicit scalp event-related components providing objective markers for high-level cognitive processing. In this way, it is possible to assess neuronal responses even in non-cooperative patients.

Our goal is:

• to study the neurophysiological basis of such markers in healthy subjects
• to develop their application to neurological pathologies, namely altered states of consciousness. In acute coma, a major clinical and care-taking focus is coma outcome prognosis. We aim at monitoring whether patients transitorily regain some degrees of consciousness, which might announce awakening. In patients in a permanent vegetative state, we focus on detecting possible residual cognitive function that cannot be revealed by traditional clinical assessment.

Publications since 2010

• Eichenlaub JB, Ruby P, Morlet D. (2012) What is the specificity of the response to the own first-name when presented as a novel in a passive oddball paradigm? An ERP study, Brain Research 1447: 65-78
• Demarquay G., Caclin A., Brudon F., Fischer C. and Morlet D. (2011) Exacerbated attention orienting to auditory stimulation in migraine patients, Clinical Neurophysiology 122(9): 1755-1763
• Fischer C, Luauté J and Morlet D (2010) Event-related potentials (MMN and novelty P3) in permanent vegetative or minimally conscious state, Clin Neurophysiol 121(7): 1032-1042